Endocrine Abstracts

Background and aim: Autoimmune hypophysitis (AH) is a rare immune-mediated inflammatory disease. Glucocorticoid therapy represents a therapeutic choice for AH patients with symptoms from mass effect, such as headache and optic nerve compression. However, effective methods and adverse events of glucocorticoid therapy are unclear. We aimed to evaluate the efficacy and safety of glucocorticoid therapy in AH patients.Patients and Methods: The subjects were a...

Introduction: Surgical treatment of giant GH cell adenomas (>4 cm in maximum diameter; GHomas) has been considered difficult. However, clinical and histological characteristics of these adenomas are still enigmatic. We retrospectively analyzed data of 17 giant GHomas experienced at Toranomon hospital to clarify their characteristics.Methods: These 17 patients, accounting for 3.1% of 549 acromegalic patients undergoing surgery between 2006 and 2011, w...

Background and aims: Excess GH causes insulin resistance resulting in impaired glucose metabolism. Although diabetes mellitus (DM) is common in patients with acromegaly, diabetic ketoacidosis (DKA) is rarely associated with acromegaly. Actually only 11 DKA patients have been anecdotally reported as the first presentation of acromegaly so far. Here we present nine cases of DKA as the first presentation of 860 consecutive patients with acromegaly and their clinical characteristi...